Anne Cathrine Kufner

In the context of maintaining consistent product quality such as a specific and narrow crystal size distribution (CSD), purity or morphology, the use of continuous crystallizers offers several advantages compared to batch crystallizers for the production of e.g. pharmaceutical products.

One of these continuous crystallizers is the slug flow crystallizer (SFC), characterized by the liquid segmentation through a gaseous phase and the maintenance of a narrow residence time distribution. This feature and the internal circulation within the liquid slugs without external devices ensure the achievement of increased product quality within very short process times.

The project focuses on the crystallization process in the apparatus, improvement in process efficiency and assurance of in-spec product crystals. Basic approach is the separation of nucleation and growth zone in order to enhance the control of crystallization phenomena.

Paper

• Anne Cathrine Kufner, Marc Meier, Kerstin Wohlgemuth
  End-to-End Continuous Small-Scale Drug Substance Manufacturing: From a Continuous In Situ Nucleator to Free-Flowing Crystalline Particles
  Crystals 2023, 13(12), 1675, doi.org/10.3390/cryst13121675
   
• Anne Cathrine Kufner, Miachel Rix, Kerstin Wohlgemuth
  Modeling of continuous slug flow cooling crystallization towards pharmaceutical applications
  Processes 2023, 11(9), 2637, doi.org/10.3390/pr11092637
   
• Anne Cathrine Kufner, Nico Westkämper, Henrik Bettin, Kerstin Wohlgemuth
  Prediction of Particle Suspension State for Various Particle Shapes Used in Slug Flow Crystallization
  Chem Engineering 2023, 7(2), 34, (doi.org/10.3390/chemengineering7020034)
   
• Anne Cathrine Kufner, Adrian Krummnow, Andreas Danzer, Kerstin Wohlgemuth
  Strategy for fast decision on material system suitability for continuous crystallization inside a Slug Flow Crystallizer
  Micromachines (2022), ( mdpi.com/2072-666X/13/10/1795)
   
• Claas Steenweg, Anne Cathrine Kufner, Jonas Habicht, Kerstin Wohlgemuth
  Towards Continuous Primary Manufacturing Processes - Particle Design through Combined Crystallization and Particle Isolation
  Processes (2021), 9, 2187, doi.org/10.3390/pr9122187
   
• Maren Termühlen, Matthias Markus Etmanski, Ines Kryschewski, Anne Cathrine Kufner, Gerhard Schembecker, Kerstin Wohlgemuth
  Continuous Slug Flow Crystallization: Impact of Design and Operating Parameters on Product Quality
  Chemical Engineering Research and Design 170 (2021) 290–303, doi.org/10.1016/j.cherd.2021.04.006

Oral presentations

• A.C. Kufner, M. Rix, K. Wohlgemuth   
  Towards autonomous continuous slug flow crystallization for small-scale applications
  22nd ISIC - International Symposium on Industrial Crystallization, Glasgow, Great Britain-Scotland (2023)
   
• A.C. Kufner, H. Bettin, N. Westkämper, K. Wohlgemuth          
  Predicting particle suspension state for different particle shapes to produce high-quality products inside a Slug Flow Crystallizer 
  Jahrestreffen der Dechema-Fachgruppe “Mehrphasenströmung”, Paderborn, Germany (2023)
   
• A.C. Kufner, M. Rix, H. Bettin, N. Westkämper, K. Wohlgemuth        
  Towards high-quality product crystals through mechanistic modeling of continuous slug flow crystallization
  Jahrestreffen der Dechema-Fachgruppe “Kristallisation”, Frankfurt, Germany (2023)
   
• A.C. Kufner, C. Steenweg, J. Habicht, K. Wohlgemuth     
  Process integration of continuous Slug Flow Crystallization and product isolation using Modular Continuous Vacuum Screw Filter     
  Jahrestreffen der ProcessNet-Fachgruppe “Kristallisation”, Dortmund, Germany (2022)
   
• A.C. Kufner, C. Steenweg, J. Habicht, K. Wohlgemuth
  Towards a continuous crystal process chain of high quality products 
  CKB-Symposium, Düsseldorf, Germany (2021)

Poster presentations

• A.C. Kufner, M. Rix, N. Westkämper, H. Bettin, K. Wohlgemuth
  Towards long-term operability and mechanistic modeling of continuous slug flow crystallization       
  Evonik meets TU Dortmund, Dortmund, Germany (2022)
   
• A.C. Kufner, C. Steenweg, J. Habicht, K. Wohlgemuth
  Particle Design through Combined Continuous Slug Flow Crystallization and Particle Isolation    
  BIWIC- 27th International Workshop on Industrial Crystallization, Espoo, Finland (2022)

• A.C. Kufner, F. Gjoni, N. Westkämper, K. Wohlgemuth
  Towards long-term operability of a continuous Slug Flow Crystallizer – Nucleation, suspension behavior, and blockage avoidance
  Jahrestreffen der ProcessNet-Fachgruppe Kristallisation, Dortmund (2022)
   
• A.C. Kufner, M. Termühlen, K. Wohlgemuth
  Towards increased product quality inside a Slug Flow Crystallizer (SFC)
  21st ISIC - International Symposium on Industrial Crystallization, Virtual Meeting (2021)
   
• A.C. Kufner, M. Termühlen, G. Schembecker, K. Wohlgemuth
  Impact of operating parameters on continuous Slug Flow Crystallization
  Jahrestreffen der ProcessNet-Fachgruppe Kristallisation, Virtual Meeting (2021)