PD Dr.-Ing. Kerstin Wohlgemuth

Patent

• Claas Steenweg, Gerhard Schembecker, Kerstin Wohlgemuth
  Rotating-Screw Drying Reactor – Schneckenfördertrocknungsreaktor
  WO 2021/148108 A1

Dissertation

• K. Wohlgemuth
  Induced Nucleation Processes during Bath Cooling Cystallization
  TU Dortmund, 2012, Verlag Dr. Hut, München, ISBN 978-3-8439-0716-3

Paper

• Maria Schlüter, Sarthak Bhutani, Jasmin Bahr, Kerstin Wohlgemuth, Christoph Held
  Measurement and PC-SAFT Modeling of the Solubility of BHET monomer, BHET dimer and PET in single solvents
  Journal of Chemical & Engineering 2024, doi.org/10.1021/acs.jced.3c00627
   
• Anne Cathrine Kufner, Marc Meier, Kerstin Wohlgemuth
  End-to-End Continuous Small-Scale Drug Substance Manufacturing: From a Continuous In Situ Nucleator to Free-Flowing Crystalline Particles
  Crystals 2023, 13(12), 1675, doi.org/10.3390/cryst13121675
   
• Astrid Ina Seifert, Hannes Wegener, Katharina Brühl, Thomas Seidensticker, Kerstin Wohlgemuth
  Polymer-Grade Bio-Monomers from Oleochemicals by Combining Homogeneous Catalysis and Selective Product Crystallization in an Integrated Process
  Processes 2023, 11 (10), 2861, doi.org/10.3390/pr11102861
   
• Anne Cathrine Kufner, Michael Rix, Kerstin Wohlgemuth
  Modeling of continuous slug flow cooling crystallization towards pharmaceutical applications
  Processes 2023, 11(9), 2637, doi.org/10.3390/pr11092637
   
• Astrid Ina Seifert, Anna Wehning, Jan Gutsch, Kerstin Wohlgemuth
  Focusing impurities during inert gassing crystallization of complex mixtures
  Organic Process Research & Development Manuscript No.: op-2023-00171q,  doi.org/10.1021/acs.oprd.3c00171
   
• Anne Cathrine Kufner, Nico Westkämper, Henrik Bettin, Kerstin Wohlgemuth
  Prediction of Particle Suspension State for Various Particle Shapes Used in Slug Flow Crystallization
  Chem Engineering 2023, 7(2), 34, doi.org/10.3390/chemengineering7020034
   
• Timo Dobler, Stefan Höving, Christian Dreiser, Marco Gleiß, Mathias Gröschen, Alexander Henkel, Manuel Hörne, Martin Schäfer, Jana Sonnenschein, Georg Wiese, Kerstin Wohlgemuth, Norbert Kockmann and Hermann Nirschl
  From Lab to Pilot Scale: Commissioning of an Integrated Device for the Generation of Crystals
  Chemical Engineering & Technology, 2023, 46(7), 1511-1520, doi.org/10.1002/ceat.202200616
   
• Matthias Markus Etmanski, Max Breloer, Marius Weber, Gerhard Schembecker, Kerstin Wohlgemuth
  Interplay of Particle Suspension and Residence Time Distribution in a Taylor-Couette Crystallizer
  Crystals 2022, 12(12), 1845; doi.org/10.3390/cryst12121845
   
• Astrid Ina Seifert, Justin Simons, Jan Gutsch, Kerstin Wohlgemuth
  Inert gassing crystallization for improved product separation of oleo-chemicals towards an efficient circular economy
  Organic Process Research & Development (12/2022), doi.org/10.1021/acs.oprd.2c00312
   
• M. Etmanski, N. Rasche, G. Schembecker, K. Wohlgemuth
  The Way to an Efficient Operation of a Continuous Taylor‐Couette Cooling Crystallizer
  Chemie Ingenieur Technik, 94 (9), 2022, doi.org/10.1002/cite.202255094
   
• Anne Cathrine Kufner, Adrian Krummnow, Andreas Danzer, Kerstin Wohlgemuth
  Strategy for fast decision on material system suitability for continuous crystallization inside a Slug Flow Crystallizer
  Micromachines (2022), mdpi.com/2072-666X/13/10/1795
   
• Jana Sonnenschein, Mario Hermes, Stefan Höving, Norbert Kockmann, Kerstin Wohlgemuth
  Population balance modeling of unstirred cooling crystallization on an integrated belt filter
  Journal Computers and Chemical Engineering (2022), doi.org/10.1016/j.compchemeng.2022.108024
   
• Janine Lins, Ute Ebeling, Kerstin Wohlgemuth
  Agglomeration Kernel Determination by Combining In-Process Image Analysis and Modeling
  Crystal Growth & Design 22, 9 (2022) 5363–5374, doi.org/10.1021/acs.cgd.2c00461
   
• Johanna Vondran, Astrid Ina Seifert, Kevin Schäfer, André Laudanski, Tabea Deysenroth, Kerstin Wohlgemuth, Thomas Seidensticker
  Progressing the Crystal Way to Sustainability: Strategy for Developing an Integrated Recycling Process of Homogeneous Catalysts by Selective Product Crystallization
  Industrial & Engineering Chemistry Research 61,27 (2022), 9621–9631, doi.org/10.1021/acs.iecr.2c00476
   
• Jana Sonnenschein, Ronja Heming, Kerstin Wohlgemuth
  Archimedes Tube Crystallizer: Design and operation of continuous cooling crystallization based on first-principle modeling
  Crystal Growth & Design 22, 9 (2022) 5272-5284, doi.org/10.1021/acs.cgd.2c00399
   
• Janine Lins, Thomas Harweg, Frank Weichert, Kerstin Wohlgemuth
  Potential of Deep Learning Methods for Deep Level Particle Characterization in Crystallization
  Applied Sciences 12, 5 (2022), 2465, doi.org/10.3390/app12052465
   
• Jana Sonnenschein, Kerstin Wohlgemuth
  Archimedes tube crystallizer: Design and characterization for small-scale continuous crystallization
  Chemical Engineering Research and Design 178 (2022) 488-501, doi.org/10.1016/j.cherd.2021.12.017
   
• Claas Steenweg, Jonas Habicht, Kerstin Wohlgemuth
  Continuous Isolation of Particles with Varying Aspect Ratios up to Thin Needles Achieving Free-Flowing Products
  Crystals 12 (2) (2022) 137, doi.org/10.3390/cryst12020137
   
• J. Sonnenschein, P. Friedrich, M. Aghayarzadeh, O. Mierka, S. Turek, K. Wohlgemuth
  Flow Map for Hydrodynamics and Suspension Behavior in a Continuous Archimedes Tube Crystallizer
  Crystals 11 (2021) 1466, doi.org/10.3390/cryst11121466
   
• Claas Steenweg, Anne Cathrine Kufner, Jonas Habicht, Kerstin Wohlgemuth
  Towards Continuous Primary Manufacturing Processes - Particle Design through Combined Crystallization and Particle Isolation
  Processes (2021), 9, 2187, doi.org/10.3390/pr9122187
   
• Claas Steenweg, Astrid Ina Seifert, Nils Böttger, Kerstin Wohlgemuth
  Process Intensification enabling Continuous Manufacturing Processes using Modular Continuous Vacuum Screw Filter
  Org. Process Res. Dev. (2021) 25, 11, 2525–2536, doi.org/10.1021/acs.oprd.1c00294
   
• Maren Termühlen, Benedikt Strakeljahn, Gerhard Schembecker, Kerstin Wohlgemuth
  Quantification and evaluation of operating parameters’ effect on suspension behavior for slug flow crystallization
  Chemical Engineering Science 243 (2021) 116771, doi.org/10.1016/j.ces.2021.116771
   
• Maren Termühlen, Matthias Markus Etmanski, Ines Kryschewski, Anne Cathrine Kufner, Gerhard Schembecker, Kerstin Wohlgemuth
  Continuous Slug Flow Crystallization: Impact of Design and Operating Parameters on Product Quality
  Chemical Engineering Research and Design 170 (2021) 290–303, doi.org/10.1016/j.cherd.2021.04.006
   
• Claas Steenweg, Astrid Ina Seifert, Gerhard Schembecker, Kerstin Wohlgemuth
• Characterization of a Modular Continuous Vacuum Screw Filter for Small-Scale Solid-Liquid Separation of Suspensions
  Org. Process Res. Dev. (2021) 25, 4, 926–940, doi.org/10.1021/acs.oprd.0c00550
   
• Claas Steenweg, Kerstin Wohlgemuth
  Von der Suspension zum getrockneten Produkt mittels neuartigem Vakuumschraubenfilter
  Filtrieren & Separieren 2021, 4, 4-11
   
• Janine Lins, Stefan Heisel, Kerstin Wohlgemuth
  Quantification of internal crystal defects using  image analysis
  Powder Technology 377 (2021) 733-738, doi.org/10.1016/j.powtec.2020.09.015
   
• Stefan Heisel, Jonas Holtkötter, Kerstin Wohlgemuth
  Measurement of agglomeration during crystallization: Is the differentiation of aggregates and agglomerates via ultrasonic irradiation possible?
  Chemical Engineering Science 210 (2019) 115214, doi.org/10.1016/j.ces.2019.115214
   
• Maren Termühlen, Benedikt Strakeljahn, Gerhard Schembecker, Kerstin Wohlgemuth
  Characterization of slug formation towards the performance of air-liquid segmented flow
  Chemical Engineering Science 207 (2019) 1288-1298, doi.org/10.1016/j.ces.2019.07.033
   
• Stefan Heisel, Janine Ernst, Arne Emshoff, Gerhard Schembecker, Kerstin Wohlgemuth
  Shape-independent particle classification for discrimination of single crystals and agglomerates
  Powder Technology 345 (2019) 425-437, doi.org/10.1016/j.powtec.2019.01.018
   
• Marie-Christine Lührmann, Jan Timmermann, Gerhard Schembecker, Kerstin Wohlgemuth
  Enhanced Product Quality Control through Separation of Crystallization Phenomena in a Four-Stage MSMPR Cascade
  Crystal Growth & Design 18 (2018) 7323-7334, doi.org/10.1021/acs.cgd.8b00941
   
• Marie-Christine Lührmann, Maren Termühlen, Jan Timmermann, Gerhard Schembecker, Kerstin Wohlgemuth
  Induced nucleation by gassing and its monitoring for the design and operation of an MSMPR cascade
  Chemical Engineering Science 192 (2018) 840-849, doi.org/10.1016/j.ces.2018.08.007
   
• Tobias Kleetz, Ricarda Scheel, Gerhard Schembecker, Kerstin Wohlgemuth
  Cooling Crystallization: Does Gassing Compete with Seeding?
  Crystal Growth & Design 19(9) (2018), doi.org/10.1021/acs.cgd.7b01781
   
• Stefan Heisel, Mareike Rolfes, Kerstin Wohlgemuth
  Discrimination between Single Crystals and Agglomerates during the Crystallization Process
  Chemical Engineering and Technology 41 (2018) 1218-1225, doi.org/10.1002/ceat.201700651
   
• Marie-Christine Lührmann, Maren Termühlen, Gerhard Schembecker, Kerstin Wohlgemuth
  Growth Rate Measurements of Organic Crystals in a Cone-Shaped Fluidized-Bed Cell
  Chemical Engineering and Technology 41 (2018) 1165-1172, doi.org/10.1002/ceat.201700683
   
• Lukas Hohmann, Thorsten Greinert, Otto Mierka, Stefan Turek, Gerhard Schembecker, Evren Bayraktar, Kerstin Wohlgemuth, Norbert Kockmann
  Analysis of Crystal Size Dispersion Effects in a Continuous Coiled Tubular Crystallizer: Experiments and Modelling
  Crystal Growth & Design 18 (2018) 1459–1473, doi.org/10.1021/acs.cgd.7b01383
   
• Lisa-Marie Terdenge, Jan Arne Kossuch, Gerhard Schembecker, Kerstin Wohlgemuth
  Potential of gassing crystallization to control the agglomeration degree of crystalline products
  Powder Technology 320 (2017) 386-396, doi.org/10.1016/j.powtec.2017.07.044
   
• Stefan Heisel, Tijana Kovačević, Heiko Briesen, Gerhard Schembecker, Kerstin Wohlgemuth
  Variable Selection and Training Set Design for Particle Classification using a Linear and a Non-Linear Classifier
  Chemical Engineering Science 173 (2017) 131-144, doi.org/10.1016/j.ces.2017.07.030
   
• Lisa-Marie Terdenge, Kerstin Wohlgemuth
  Effect of drying method on agglomeration degree of crystalline products
  Chemical Engineering Science 167 (2017) 88-97, doi.org/10.1016/j.ces.2017.04.003
   
• Julia Sieberz, Elif Cinar, Kerstin Wohlgemuth, Gerhard Schembecker
  Clarification of a monoclonal antibody with cationic polyelectrolytes: analysis of influencing parameters
  Biochemical Engineering Journal 122 (2017) 60–70, doi.org/10.1016/j.bej.2017.02.011
   
• Tobias Kleetz, Gordon Paetzold, Gerhard Schembecker, Kerstin Wohlgemuth
  Gassing Crystallization at Different Scales: Potential to Control Nucleation and Product Properties
  Crystal Growth & Design 17 (2017) 1028–103, doi.org/10.1021/acs.cgd.6b01280
   
• Tobias Kleetz, Felix Funke, Annika Sunderhaus, Gerhard Schembecker, Kerstin Wohlgemuth
  Influence of Gassing Crystallization Parameters on Induction Time and Crystal Size Distribution
  Crystal Growth & Design 16 (2016)  6797-6803, doi.org/10.1021/acs.cgd.6b00895
   
• Lisa-Marie Terdenge,  Kerstin Wohlgemuth
  Impact of agglomeration on crystalline product quality within the crystallization process chain
  Crystal Research & Technology 51 (2016) 513-523, doi.org/10.1002/crat.201600125
   
• Lukas Hohmann, Ramona Gorny, Oliver Klaas, Jonas Ahlert, Kerstin Wohlgemuth, Norbert Kockmann
  Design of a Continuous Tubular Cooling Crystallizer for Process Development on Lab-scale
  Chemical Engineering & Technology 39 (2016) 1268-1280, doi.org/10.1002/ceat.201600072
   
• Tobias Kleetz, Florian Braak, Nils Wehenkel, Gerhard Schembecker, Kerstin Wohlgemuth
  Design of Median Crystal Diameter Using Gassing Crystallization and Different Process Concepts
  Crystal Growth & Design 16 (2016) 1320-1328, doi.org/10.1021/acs.cgd.5b01428
   
• Julia Sieberz, Kerstin Wohlgemuth, Gerhard Schembecker
  The influence of impurity proteins on the precipitation of a monoclonal antibody with an anionic polyelectrolyte
  Separation and Purification Technology 146 (2015) 252-260, doi.org/10.1016/j.seppur.2015.03.055
   
• Lisa-Marie Terdenge, Stefan Heisel, Gerhard Schembecker, Kerstin Wohlgemuth
  Agglomeration degree distribution as quality criterion to evaluate crystalline products
  Chemical Engineering Science 133 (2015) 157-169, doi.org/10.1016/j.ces.2015.03.002
   
• Julia Sieberz, Bernd Stanislawski, Kerstin Wohlgemuth, Gerhard Schembecker
  Identification of parameter interactions influencing the precipitation of a monoclonal antibody with anionic polyelectrolytes
  Separation and Purification Technology 127 (2014) 165–173, doi.org/10.1016/j.seppur.2014.02.033
   
• Kerstin Wohlgemuth and Gerhard Schembecker
  Modeling Induced Nucleation Processes during Batch Cooling Crystallization: A Sequential Parameter Determination Procedure
  Computers & Chemical Engineering 52 (2013) 216-229, doi.org/10.1016/j.compchemeng.2012.12.001
   
• Kerstin Wohlgemuth, Feelly Ruether, Gerhard Schembecker
  Sonocrystallization and Crystallization with Gassing of Adipic Acid
  Chemical Engineering Science 65 (2010) 1016-1027, doi.org/10.1016/j.ces.2009.09.055
   
• Kerstin Wohlgemuth, Anna Kordylla, Feelly Ruether, Gerhard Schembecker
  Experimental Study of the Effect of Bubbles on Nucleation during Batch Cooling Crystallization
  Chemical Engineering Science 64 (2009) 4155-4163, doi.org/10.1016/j.ces.2009.06.041

Book Contributions

• K. Wohlgemuth (editor)
  BIWIC 17 - 24th International Workshop on Industrial Crystallization
  Verlag Dr. Hut, ISBN 978-3-8439-3247-9
   
• S. Heisel, L.-M. Terdenge, K. Wohlgemuth
  Eine Strategie Zur Charakterisierung und dem Design organischer kristalliner Produkte
  In: Produktgestaltung in der Partikeltechnologie, Band 8, pp. 33-40
  Fraunhofer Verlag, ISBN 978-3-8396-1194-4

Oral presentations

• A.C. Kufner, M. Rix, K. Wohlgemuth   
  Towards autonomous continuous slug flow crystallization for small-scale applications
  22nd ISIC - International Symposium on Industrial Crystallization, Glasgow, Great Britain-Scotland (2023)
   
• A.C. Kufner, H. Bettin, N. Westkämper, K. Wohlgemuth          
  Predicting particle suspension state for different particle shapes to produce high-quality products inside a Slug Flow Crystallizer 
  Jahrestreffen der Dechema-Fachgruppe “Mehrphasenströmung”, Paderborn, Germany (2023)
   
• A.C. Kufner, M. Rix, H. Bettin, N. Westkämper, K. Wohlgemuth        
  Towards high-quality product crystals through mechanistic modeling of continuous slug flow crystallization
  Jahrestreffen der Dechema-Fachgruppe “Kristallisation”, Frankfurt, Germany (2023)
   
• A.C. Kufner, C. Steenweg, J. Habicht, K. Wohlgemuth     
  Process integration of continuous Slug Flow Crystallization and product isolation using Modular Continuous Vacuum Screw Filter     
  Jahrestreffen der ProcessNet-Fachgruppe “Kristallisation”, Dortmund, Germany (2022)
   
• A.C. Kufner, C. Steenweg, J. Habicht, K. Wohlgemuth
  Towards a continuous crystal process chain of high quality products 
  CKB-Symposium, Düsseldorf, Germany (2021)
   
• C. Steenweg, J. Habicht, K. Wohlgemuth
  Continuous Particle Isolation by Solid-Liquid Separation, Washing, and Drying using the Small-Scale Continuous Vacuum Screw Filter
  3th European Congress of Chemical Engineering and 6th European Congress of Applied Biotechnology (2021)
   
• C. Steenweg, J. Habicht, G. Schembecker, K. Wohlgemuth
  Integrated Process Design of Continuous Solid-Liquid Separation, Washing, and Drying for Crystal Suspensions with Varying Crystal Shapes
  21st ISIC - International Symposium on Industrial Crystallization (2021)
   
• C. Steenweg, A. Seifert, G. Schembecker, K. Wohlgemuth
  Characterization of a Continuous Small-Scale Solid-Liquid Separator for Filtration, Washing, and Drying of Pharmaceutical Suspensions
  12th PBP World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (2021)
   
• C. Steenweg, N. Böttger, A. Seifert, G. Schembecker, K. Wohlgemuth
  Holistic product quality control throughout the crystallization process chain focusing on continuous crystal isolation
  Jahrestreffen der ProcessNet-Fachgruppe Kristallisation (2021)
   
• C. Steenweg, N. Böttger, G. Schembecker, K. Wohlgemuth
  Characterizing the Residence Time Distribution and Washing Zone within an Innovative Continuous Small-Scale Solid-Liquid Separator
  Jahrestreffen der ProcessNet-Fachgruppe Mechanische Flüssigkeitsabtrennung (2021)
   
• Claas Steenweg, Gerhard Schembecker, Kerstin Wohlgemuth
  Crystal Product Design of Amino- and Dicarboxylic Acids
  CKB-Symposium, Düsseldorf, Germany (2019)
   
• K. Wohlgemuth, M.-C. Ostermann
  From Batch to Continuous Crystallizsation - New Process Concepts
  MT Kristallisations-Symposium, Basel, Switzerland (2017)
   
• T. Kleetz, R. Scheel, G. Schembecker, and K. Wohlgemuth
  Increase of production capacity using gassing crystallization
  20^th International Symposium on Industrial Crystallization, Dublin, Ireland (2017)
   
• S. Heisel, L.-M. Terdenge, K. Wohlgemuth
  A strategy to characterize and design oganic crystalline products
  8. Symposium Produktgestaltung in der Partikeltechnologie, Karlsruhe, Germany (2017)
   
• S. Heisel, L.-M. Terdenge, K. Wohlgemuth
  Optimization of Crystal product Properties by Preventing Undesired Agglomeration
  MT Kristallisations-Symposium, Frankfurt, Germany (2016)
   
• K. Wohlgemuth, L.-M. Terdenge and G. Schembecker
  Crystal Product Design: From Crystal Formation to Its Final Solid Form
  New Frontiers for Biotech Processes, Koblenz, Germany (2016)
   
• K. Wohlgemuth, L. Petrat, T. Kleetz, and G. Schembecker
  Evaluation of Agglomeration Processes during the Crystallization of Adipic Acid
  Jahrestreffen der ProcessNet-Fachgruppe Kristallisation, Frankfurt, Germany (2016)
   
• K. Wohlgemuth
  Product Design: From crystal formation to its final solid form
  MT Kristallisations-Symposium, Basel, Switzerland (2014)
   
• K. Wohlgemuth and G. Schembecker
  Sequential parameter determination during crystallization process modeling
  Jahrestreffen der Fachgruppen Agglomerations- und Schüttguttechnik & Kristallisation, Wittenberg, Germany (2012)
   
• K. Wohlgemuth, F. Rüther, and G. Schembecker
  Crystallization of Fatty Acids on Bubble Surfaces using Ultrasound or Gassing
  Vortrags- und Diskussionstagung: Bioverfahrenstechnik an Grenzflächen, Potsdam, Germany (2011)

Poster presentations

• A.C. Kufner, M. Rix, N. Westkämper, H. Bettin, K. Wohlgemuth
  Towards long-term operability and mechanistic modeling of continuous slug flow crystallization       
  Evonik meets TU Dortmund, Dortmund, Germany (2022)
   
• A.C. Kufner, C. Steenweg, J. Habicht, K. Wohlgemuth
  Particle Design through Combined Continuous Slug Flow Crystallization and Particle Isolation    
  BIWIC- 27th International Workshop on Industrial Crystallization, Espoo, Finland (2022)
   
• A.C. Kufner, F. Gjoni, N. Westkämper, K. Wohlgemuth
  Towards long-term operability of a continuous Slug Flow Crystallizer – Nucleation, suspension behavior, and blockage avoidance
  Jahrestreffen der ProcessNet-Fachgruppe “Kristallisation”, Dortmund, Germany (2022)
   
• A.C. Kufner, M. Termühlen, K. Wohlgemuth 
  Towards increased product quality inside a Slug Flow Crystallizer (SFC)  
  21st ISIC - International Symposium on Industrial Crystallization, Virtual Meeting (2021)
   
• A.C. Kufner, M. Termühlen, G. Schembecker, K. Wohlgemuth
  Impact of operating parameters on continuous Slug Flow Crystallization   
  Jahrestreffen der ProcessNet-Fachgruppe “Kristallisation”, Virtual Meeting (2021)
   
• S. Heisel, J. Schoen, A.-L. Diekmann, and K. Wohlgemuth
  Online measurement of the agglomeration degree of adipic acid during batch cooling crystallization
  20^th International Symposium on Industrial Crystallization, Dublin, Ireland (2017)
   
• L. Terdenge and K. Wohlgemuth
  The influence of downstream processes on the crystal size distribution of organic solids
  19^th International Symposium on Industrial Crystallization, Toulouse, France (2014)
   
• K. Wohlgemuth,  F. Ruether, und G. Schembecker
  Towards Understanding of Induced Nucleation Phenomena
  18^th International Symposium on Industrial Crystallization, Zurich, Switzerland (2011)
   
• F. Rüther, D. Fuchs, K. Wohlgemuth, G. Sadowski, G. Schembecker
  Modellierung von Batchkristallisation - unabhängige Bestimmung von Keimbildungs- und Wachstumskinetik
  Jahrestreffen des Fachausschusses Kristallisation, Magdeburg (2010)
   
• K. Wohlgemuth, F. Ruether, and G. Schembecker
  Experimental Study on Nucleation during Crystallization of Adipic Acid
  Jahrestreffen der Fachausschüsse Kristallisation und Fluidverfahrenstechnik, Dortmund (2009)