Dr.-Ing. Kai Stückenschneider

Kai Stückenschneider studied Molecular Biology (B.Sc.) at the University of Applied Sciences (UAS) Gelsenkirchen. He finished his Bachelor studies with an external thesis at the „University of Edinburgh Centre for Cardiovascular Science“ dealing with the establishment of Optical Projection Chromatography in order to examine renal development during murine development.

Hereafter, he graduated in Molecular Biology focussing on bioengineering at the UAS Gelsenkirchen. During his associated Research Project / Master Thesis he was busy on the Process development of Alternative adsorbents for the purification of a polyclonal immunoglobulin preparation at Fresenius Biotech GmbH in Munich.

From 2010 till 2013 he was working at the Laboratory of Plant and Process Design of TU Dortmund on his PhD. In his research he focused on the Identification of molecular mechanisms during adsorption of amino acids and proteins from complex aqueous media.

Downstream processing is still the most costly part of biotechnological processes. A deeper understanding of the underlying molecular mechanisms of downstream processes can help to facilitate process design and the generation of heuristics. In this project, we investigate the intrinsic mechanisms of adsorption of amino acids and proteins. We start at the base of the separation step (adsorption), namely at the molecular level.
This requires a solid base of experiments, e.g., column experiments with standard amino acid solutions and later with more complex mixtures that may contain other metabolites. This is supported by modeling at the molecular level to identify the entities involved in adsorption and to determine structural changes in the amino acid/protein molecules. Finally, based on this in-depth knowledge at the molecular level, heuristics can be developed to facilitate scale-up and downstream processes in a more cost-effective manner.

Dissertation

• K. Stückenschneider
  Molecular Modeling of Adsorptive Interactions between Small Organic Molecules and Zeolites
  TU Dortmund, 2014, Verlag Dr. Hut, München, ISBN 978-3-8439-1642-4

Oral presentations

• K. Stueckenschneider, J. Merz, G. Schembecker 
  Com­bined microcalorimetric and DFT study of amino acid adsorption in zeolites
  Jahrestreffen der Fachgruppe Adsorption, Bad Wildungen (2013)
   
• K. Stueckenschneider, J. Merz, G. Schembecker 
  Potentials of zeolites in the separation of bio-products: a combined computational and experimental characterization
  9th International PhD Seminar on Chromatographic Sepa­ration Science, Weggis, Switzerland (2013)
   
• K. Stueckenschneider, J. Merz, V. Milman, G. Schembecker
  Theoretical and Experimental Study of the pH-dependent Interaction of Amino Acids and MFI-type zeolite
  8th German Conference on Chemoinformatics, Goslar (2012)
   
• K. Stueckenschneider, J. Merz, A. Zielesny, G. Schembecker
  Adsorption von Aminosäuren an einen Zeolithen vom Typ MFI: Computerunterstützte und experimentelle Ergebnisse
  ProcessNet-Jahrestagung und 30. DECHEMA-Jahrestagung der Biotechnologen 2012, Karlsruhe (2012)
   
• K. Stueckenschneider, A. Zielesny, G. Schembecker
  Adsorption of Amino Acids on MFI type Zeolite: Experimental results and DFT calculations
  Jahrestreffen der Fachgruppe Adsorption, Magdeburg (2012)
   
• K. Stueckenschneider, A. Zielesny, G. Schembecker 
  Adsorption of Amino Acids on MFI type Zeolite: Experimental results and DFT calculations
  Doktorandenseminar Chromatographische Trennprozesse, Freudenstadt-Lauterbad (2012)
   
• K. Stueckenschneider, A. Zielesny, G. Schembecker 
  Adsorption of Amino Acids on MFI type Zeolite: Microcalorimetric study and DFT calculation
  Third Annual CLIB-Graduate Cluster Retreat, Bergisch Gladbach (2012)

Poster presentations

• K. Stueckenschneider, J. Merz, A. Zielesny, G. Schembecker
  Adsorption of amino acids in MFI-type zeolite: a computational and experimental study
  15th European Congress on Biotechnology, Istanbul, Turkey (2012)
   
• K. Stueckenschneider, A. Zielesny, G. Schembecker
  Adsorption of Alanine and Phenylalanine on MFI-type Zeolite: DFT Calculations and Experimental Results
  26th Molecular Modeling Workshop, Erlangen (2012)
   
• K. Stueckenschneider, A. Zielesny, G. Schembecker
  Adsorption of Amino Acids on MFI type Zeolite: Experimental results and DFT calculations
  Third Annual CLIB-Graduate Cluster Retreat, Bergisch Gladbach (2012)
   
• K. Stueckenschneider, A. Zielesny, G. Schembecker
  Adsorption of Amino Acids on MFI type Zeolite: Experimental results and DFT calculations
  7th German Conference on Chemoinformatics, Goslar (2011)
   
• K. Stueckenschneider, G. Schembecker
  Adsorption of alanine to different adsorbents: comparison of ab initio modeling and experimental data
  1st European Congress of Applied Biotechnology, Berlin (2011)
   
• K. Stueckenschneider, G. Schembecker, B. Burghoff
  Development of in silico models for MFI-type zeolites and polymeric resins to examine the molecular interactions with amino acids using quantum mechanics
  Second Annual CLIB-Graduate Cluster Retreat, Bonn (2011)
   
• K. Stueckenschneider, G. Schembecker, B. Burghoff
  Development of in silico models for MFI-type zeolites and polymeric resins to examine the molecular interactions with amino acids using quantum mechanics
  CLIB 2021 Industrielle Biotechnologie, 2nd CLIB Interna­tional Conference, Düsseldorf (2011)