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Fakultät Bio- und Chemieingenieurwesen
© LS APT​/​TU Dortmund
Alumni

Dr.-Ing. Irene Kaplanow

Profile picture: Irene Kaplanow

Curriculum Vitae

Born July 11th, 1988 in Ajagus (Kazakhstan)
1999-2008 St. Michael-Gymnasium,
Ahlen (Germany)
2008-2012 B.Sc. Biochemical Engineering Studies, TU Dortmund University,
Bachelor thesis: Purification of 1,3-Propanediol using ionic liquid based aqueous two-phase systems
2012-2014 M. Sc. Biochemical Engineering Studies, TU Dortmund University,
Master thesis: Purification of interferon alpha-2b using centrifugal partition chromatography
2014-2017 PhD at the Laboratory of Plant and Process Design, TU Dortmund University,
Field of research: Tunable Aqueous Polymer Phase Impregnated Resins (TAPPIR®)- Technology - A novel approach for the separation and purification of biomolecules

Field of Research

Tunable Aqueous Polymer Phase Impregnated Resins (TAPPIR®)- Technology is a novel approach for the separation and purification of biomolecules. The TAPPIR®- Technology is based on the immobilization of one aqueous polymer phase inside the pores of a solid, while the second aqueous phase forms the bulk liquid around the impregnated solids.

Thus it provides a biocompatible environment for biologically active molecules eliminating phase separation step and long settling times, which are limiting the industrial application of Aqueous Two Phase Extraction (ATPE). Aim of this work is the investigation of the TAPPIR®- Technology for downstream processing of proteins.

Publications

Dissertation

  • I. Kaplanow
    Advances in Separation of Biochemical Molecules utilizing Tunable Aqueous Polymer Phase Impregnated Reins
    TU Dortmund, 2019, Verlag Dr. Hut, München ISBN 978-3-8439-4192-1  

Paper

  • Kaplanow, I., Goerzgen, F., Merz, J., Schembecker, G.
    Mass Transfer of Proteins in Aqueous Two-Phase Systems
    Scientific Reports 9(1) ( 2019) 3692, Article
     
  • Kaplanow, I., Stecker, J., Schembecker, G., Merz, J.
    Multistage Processing of Tunable Aqueous Polymer Phase Impregnated Resins (TAPPIR®)
    Chemical Engineering and Technology41(7)(2018), pp. 1324-1330, doi.org/10.1002/ceat.201800079
     
  • I. Kaplanow, M. Schmalenberg, I. Borgmann, G. Schembecker, J. Merz
    Tunable Aqueous Polymer Phase Impregnated Resins (TAPPIR®): Investigation of the impregnation stability
    Separation and Purification Technology, 190 (2017) 1-8, doi.org/10.1016/j.seppur.2017.08.022

Oral presentations

  • Irene Kaplanow, Gerhard Schembecker, Juliane Merz
    Development of a method for a fast determination of the impregnation stability for the Tunable Aqueous Polymer Phase Impregnated Resins (TAPPIR®)-Technology
    13th International PhD Seminar on Chromatographic Separation Science, Annweiler am Trifels, Germany (2017)
  • I. Kaplanow, G. Schembecker and J. Merz
    Tunable Aqueous Polymer Phase Impregnated Resins (TAPPIR®)-Technology for Protein Purification
    ProcessNet-Jahrestagung und 32. DECHEMA-Jahrestagung der Biotechnologen, Aachen, Germany (2016)
     
  • Irene Kaplanow, Gerhard Schembecker, Juliane Merz
    Development of the Tunable Aqueous Polymer Phase Impregnated Resins Technology in packed bed operation
    12th International PhD Seminar on Chromatographic Separation Science 2016, Schleiden, Germany (2016)
     
  • Irene Kaplanow, Gerhard Schembecker, Juliane Merz
    Impregnation Stability of the Tunable Aqueous Polymer Phase Impregnated Resins
    Seventh Annual Retreat of the CLIB-Graduate Cluster, Herdecke, Germany (2016)
     
  • I.Kaplanow, G. Schembecker and J.Merz
    Tunable Aqueous Polymer Phase Impregnated Resins Technology - Investigation of Impregnation Stability
    Affinity 2015 21st Biennial Meeting of the International Society for Molecular Recognition, Puerto Vallarta, Mexico
  • I.Kaplanow, G. Schembecker and J.Merz
    Tunable Aqueous Polymer Phase Impregnated Resins Technology – A technology for downstream processing of biomolecules
    18th International conference in Biopartitioning and purification, Vienna, Austria (2015)
  • Irene Kaplanow, Gerhard Schembecker, Juliane Merz
    Tunable Aqueous Polymer Phase Impregnated Resins -  A technology for downstream processing of biomolecules
    11th PhD Seminar on Chromatographic Separation Science 2015, Sundern, De (2015)

Poster presentations

  • Irene Kaplanow, Gerhard Schembecker, Juliane Merz
    Tunable Aqueous Polymer Phase Impregnated Resins: Contact angle as prediction parameter for impregnation
    31st Conference of European Colloid and Interface Society, Madrid, Spain (2017)
     
  • Irene Kaplanow, Gerhard Schembecker, Juliane Merz
    Tunable Aqueous Polymer Phase Impregnated Resins (TAPPIR®) for protein separation: Investigation of the impregnation stability
    Models for Developing and Optimising Biotech Production, Neu-Ulm Germany (2017)
     
  • Irene Kaplanow, Gerhard Schembecker, Juliane Merz
    Impregnation Stability of Tunable Aqueous Polymer Phase Impregnated Resins
    New Frontiers for Biotech Processes, Koblenz, Germany (2016)
     
  • Irene Kaplanow, Gerhard Schembecker, Juliane Merz
    Impregnation Stability of the Tunable Aqueous Polymer Phase Impregnated Resins
    Seventh Annual Retreat of the CLIB-Graduate Cluster, Herdecke, Germany (2016)
     
  • Irene Kaplanow, Gerhard Schembecker, Juliane Merz
    Tunable Aqueous Polymer Phase Impregnated Resins Technology – Investigation of impregnation stability
    Scale-up and scale-down of bioprocesses, Hamburg, Germany (2015)
  • I.Kaplanow, G. Schembecker, J. Merz
    Tunable Aqueous Polymer Phase Impregnated Resins Technology – A technology for downstream processing of biological products
    Sixth Annual CLIB-Graduate Retreat, Wermelskirchen, Deutschland (2015)
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