Dr.-Ing. Moritz Peterwitz
Curriculum Vitae
| Born | November 3rd 1992, Bochum (Germany) |
| 2004-2012 | Graf-Engelbert-Schule (Bochum) |
| 2012-2016 | B.Sc. Chemical Engineering, TU Dortmund University Bachelor thesis: Experimental investigation of the influence of solvent viscosity in organic solvent nanofiltration |
| 2016-2017 | M.Sc. Chemical Engineering, TU Dortmund University Master thesis: Parameter study for optimisation of space-time-yield in the siphon reactor |
| 2018-2020 | PhD at Invite GmbH (Leverkusen) in cooperation with the Laboratory of Plant and Process Design (TU Dortmund) within the frame of the consortium DDIC |
Field of Research
Currently, most pharmaceutical processes for producing solid oral dosage forms like tablets are operated in batch mode. But, continuous manufacturing (CM) as it has been performed in other industries for years offers many advantages. However, CM has no broad application until now because there is still a missing in process understanding. As a consequence, this work focuses on modeling and predicting disturbances in CM and their propagation through the process chain. For this purpose, device models will be developed and integrated into a process model. On this way, understanding of process dynamics in CM should be improved.
This work is a cooperation of INVITE GmbH and TU Dortmund within the frame of the academic-industrial consortium Drug Delivery Innovation Center (DDIC).
Recommended for further reading
[1] P. Kleinebudde, J. Khinast, J. Rantanen, Continuous Manufacturing of Pharmaceuticals, Advances in Pharmaceutical Technology, John Wiley & Sons Incorporated, Newark 2017.
[2] L. B. Bohle, Continuous Processing Unit QbCon - Your Continuous Manufacturing Starts Here, www.continuous-production.com/continuous-processing-unit, accessed 23 February 2018.
Publications
Dissertation
- M. Peterwitz
A Contribution to Disturbance Prediction in Continuous Manufacturing of Solid Oral Dosage Forms
TU Dortmund, 2023, Verlag Dr. Hut, München, ISBN 978-3-8439-5341-2
Paper
- M. Peterwitz, S. Gerling, G. Schembecker
Corrigendum to “Challenges in tracing material flow passing a loss-in-weight feeder in continuous manufacturing processes”
International Journal of Pharmaceutics (2022) 612, doi.org/10.1016/j.ijpharm.2022.122077 - M. Peterwitz, S. Buchgeister, R. Meier, G. Schembecker
Tracking raw material flow through a continuous direct compression line. Part II of II: Predicting dynamic changes in quality attributes of tablets due to disturbances in raw material properties using an independent residence time distribution model
International Journal of Pharmaceutics, Volume 615, March 2022, 121528, doi.org/10.1016/j.ijpharm.2022.121528
- M. Peterwitz, J. Jodwirschat, R. Loll, G. Schembecker
Tracking raw material flow through a continuous direct compression line Part I of II: Residence time distribution modeling and sensitivity analysis enabling increased process yield
International Journal of Pharmaceutics, Volume 614, February 2022, 121467, doi.org/10.1016/j.ijpharm.2022.121467
- M. Peterwitz, S. Gerlng, G. Schembecker
Challenges in tracing material flow passing a loss-in-weight feeder in continuous manufacturing processes
International Journal of Pharmaceutics, Volume 61225, January 2022, 121304, doi.org/10.1016/j.ijpharm.2021.121304
- M. Peterwitz, G. Schembecker
Evaluating the potential for optimization of axial back mixing in continuous pharmaceutical manufacturing
Computers and Chemical Engineering 04.02 (2021) 107251, ddoi.org/10.1016/j.compchemeng.2021.107251