Dr.-Ing. Stefan Heisel
Curriculum Vitae
| Born | 19.07.1988 in Herne (Germany) |
| 1999-2008 | Adalbert-Stifter-Gymnasium, Castrop-Rauxel (Germany) |
| 2009-2013 | B.Sc. Biochemical Engineering Studies, TU Dortmund University Bachelor thesis: Development of an Image Analysis Tool to Determine the Agglomeration Degree of Crystalline Products |
| 2012 | Semester abroad at Hong Kong University of Science and Technology (Hong Kong) |
| 2013-2015 | M.Sc. Biochemical Engineering Studies, TU Dortmund University Master thesis: Formation of Pharmaceutical Cocrystals from Solvent Mixtures |
| 2016-2018 | PhD at the Laboratory of Plant and Process Design, TU Dortmund University Field of research: Investigation of agglomeration processes during organic compound crystallization |
Field of Research
Crystallization is a common technique for separation, purification as well as product design of organic compounds. Due to the increasing demand in specific product characteristics, optimization of the crystallization process is of high interest. Crystalline products are widely characterized by the crystal size distribution (CSD); however, no information is given about the agglomeration –the bonding of single crystals by solid bridges - of the crystals.
In this work, the focus is on the agglomeration processes occurring during crystallization. For this matter, a new experimental setup is developed that uses image analysis to make high quality videos of the crystal suspension. Image analysis and sophisticated classification tools that were already developed in the past (Terdenge et al., 2015), are used to distinguish between the different types of crystals. The aim is gain a more detailed understanding of the agglomeration processes and to use this knowledge for optimization of the crystallization process
Publication
Dissertation
- S. Heisel
Contribution to Quantification of Crystalline Product Quality using Image Analysis
TU Dortmund, 2021, Verlag Dr. Hut, München, ISBN 978-3-8439-4900-2
Paper
- S. Heisel, J. Holtkötter, K. Wohlgemuth
Measurement of agglomeration during crystallization: Is thedifferentiation of aggregates and agglomerates via ultrasonic irradiation possible?
Chemical Engineering Science 210 (2019) 115214, doi.org/10.1016/j.ces.2019.115214
- S. Heisel, J. Ernst, A. Emshoff, G. Schembecker, K. Wohlgemuth
Shape-independent particle classification for discrimination of single crystals and agglomerates
Powder Technology 345 (2019) 425-437, doi.org/10.1016/j.powtec.2019.01.018
- S. Heisel, M. Rolfes, K. Wohlgemuth
Discrimination between Single Crystals and Agglomerates during the Crystallization Process
Chemical Engineering & Technology 41 (6) (2018) 1218-1225, doi.org/10.1002/ceat.201700651
- S. Heisel; T. Kovačević; H. Briesen, G.Schembecker, K. Wohlgemuth
Variable Selection and Training Set Design for Particle Classification using a Linear and a Non-Linear Classifier
Chemical Engineering Science 173 (2017) 131-144, doi.org/10.1016/j.ces.2017.07.030
- L.-M. Terdenge, S. Heisel, G. Schembecker, K. Wohlgemuth
Agglomeration degree distribution as quality criterion to evaluate crystalline products
Chemical Engineering Science 133 (2015) 157-169, doi.org/10.1016/j.ces.2015.03.002
Conference Proceedings
- S. Heisel , M. Rolfes, K. Wohlgemuth
Image-based discrimination of single crystals and agglomerates during batch cooling crystallization
Proceedings of the 25th International Workshop on Industrial Crystallization “BIWIC” (2018) 195-200
- S. Heisel, J. Schön, A.-L. Diekmann, G. Schembecker, K. Wohlgemuth
Evolution of the agglomeration degree over time during batch cooling crystallization
Proceedings of the 24th International Workshop on Industrial Crystallization “BIWIC” (2017) 60-65
Verlag Dr. Hut, ISBN 978-3-8439-3247-
Oral presentations
- S. Heisel, M. Rolfes, K. Wohlgemuth
Differentiation of adipic acid aggregates and agglomerates during batch cooling crystallization
Jahrestreffen der ProcessNet-Fachgruppe “Kristallisation”, Bremen, DEU (2018)
- S. Heisel, J. Schön, A.-L. Diekmann, G. Schembecker, K. Wohlgemuth
Evolution of the agglomeration degree over time during batch cooling crystallization
24th International Workshop on Industrial Crystallization “BIWIC”, Dortmund, DEU (2017)
- S. Heisel, A.-L. Diekmann, G. Schembecker, K. Wohlgemuth
Online Investigation of Agglomeration Processes during Batch Cooling Crystallization
Jahrestreffen der ProcessNet-Fachgruppe “Kristallisation”, Köln, DEU (2017)
Poster presentations
- S. Heisel, M. Rolfes, K. Wohlgemuth
Image-based discrimination of single crystals and agglomerates during batch cooling crystallization: Necessity of disaggregation for accurate measurement
25th International Workshop on Industrial Crystallization “BIWIC”, Rouen, FRA (2018)
- S. Heisel, J. Schön, A.-L. Diekmann, G. Schembecker, K. Wohlgemuth
Online measurement of the agglomeration degree of adipic acid during batch cooling crystallization
20th International Symposium on Industrial Crystallization “ISIC”, Dublin, IRL (2017)