Dr.-Ing. Irene Kaplanow

Tunable Aqueous Polymer Phase Impregnated Resins (TAPPIR®)- Technology is a novel approach for the separation and purification of biomolecules. The TAPPIR®- Technology is based on the immobilization of one aqueous polymer phase inside the pores of a solid, while the second aqueous phase forms the bulk liquid around the impregnated solids.

Thus it provides a biocompatible environment for biologically active molecules eliminating phase separation step and long settling times, which are limiting the industrial application of Aqueous Two Phase Extraction (ATPE). Aim of this work is the investigation of the TAPPIR®- Technology for downstream processing of proteins.

Dissertation

• I. Kaplanow
  Advances in Separation of Biochemical Molecules utilizing Tunable Aqueous Polymer Phase Impregnated Reins
  TU Dortmund, 2019, Verlag Dr. Hut, München ISBN 978-3-8439-4192-1  

Paper

• Kaplanow, I., Goerzgen, F., Merz, J., Schembecker, G.
  Mass Transfer of Proteins in Aqueous Two-Phase Systems
  Scientific Reports 9(1) ( 2019) 3692, Article
   
• Kaplanow, I., Stecker, J., Schembecker, G., Merz, J.
  Multistage Processing of Tunable Aqueous Polymer Phase Impregnated Resins (TAPPIR®)
  Chemical Engineering and Technology41(7)(2018), pp. 1324-1330, doi.org/10.1002/ceat.201800079
   
• I. Kaplanow, M. Schmalenberg, I. Borgmann, G. Schembecker, J. Merz
  Tunable Aqueous Polymer Phase Impregnated Resins (TAPPIR®): Investigation of the impregnation stability
  Separation and Purification Technology, 190 (2017) 1-8, doi.org/10.1016/j.seppur.2017.08.022

Oral presentations

• Irene Kaplanow, Gerhard Schembecker, Juliane Merz
  Development of a method for a fast determination of the impregnation stability for the Tunable Aqueous Polymer Phase Impregnated Resins (TAPPIR®)-Technology
  13th International PhD Seminar on Chromatographic Separation Science, Annweiler am Trifels, Germany (2017)

• I. Kaplanow, G. Schembecker and J. Merz
  Tunable Aqueous Polymer Phase Impregnated Resins (TAPPIR®)-Technology for Protein Purification
  ProcessNet-Jahrestagung und 32. DECHEMA-Jahrestagung der Biotechnologen, Aachen, Germany (2016)
   
• Irene Kaplanow, Gerhard Schembecker, Juliane Merz
  Development of the Tunable Aqueous Polymer Phase Impregnated Resins Technology in packed bed operation
  12th International PhD Seminar on Chromatographic Separation Science 2016, Schleiden, Germany (2016)
   
• Irene Kaplanow, Gerhard Schembecker, Juliane Merz
  Impregnation Stability of the Tunable Aqueous Polymer Phase Impregnated Resins
  Seventh Annual Retreat of the CLIB-Graduate Cluster, Herdecke, Germany (2016)
   
• I.Kaplanow, G. Schembecker and J.Merz
  Tunable Aqueous Polymer Phase Impregnated Resins Technology - Investigation of Impregnation Stability
  Affinity 2015 21st Biennial Meeting of the International Society for Molecular Recognition, Puerto Vallarta, Mexico

• I.Kaplanow, G. Schembecker and J.Merz
  Tunable Aqueous Polymer Phase Impregnated Resins Technology – A technology for downstream processing of biomolecules
  18th International conference in Biopartitioning and purification, Vienna, Austria (2015)

• Irene Kaplanow, Gerhard Schembecker, Juliane Merz
  Tunable Aqueous Polymer Phase Impregnated Resins -  A technology for downstream processing of biomolecules
  11th PhD Seminar on Chromatographic Separation Science 2015, Sundern, De (2015)

Poster presentations

• Irene Kaplanow, Gerhard Schembecker, Juliane Merz
  Tunable Aqueous Polymer Phase Impregnated Resins: Contact angle as prediction parameter for impregnation
  31st Conference of European Colloid and Interface Society, Madrid, Spain (2017)
   
• Irene Kaplanow, Gerhard Schembecker, Juliane Merz
  Tunable Aqueous Polymer Phase Impregnated Resins (TAPPIR®) for protein separation: Investigation of the impregnation stability
  Models for Developing and Optimising Biotech Production, Neu-Ulm Germany (2017)
   
• Irene Kaplanow, Gerhard Schembecker, Juliane Merz
  Impregnation Stability of Tunable Aqueous Polymer Phase Impregnated Resins
  New Frontiers for Biotech Processes, Koblenz, Germany (2016)
   
• Irene Kaplanow, Gerhard Schembecker, Juliane Merz
  Impregnation Stability of the Tunable Aqueous Polymer Phase Impregnated Resins
  Seventh Annual Retreat of the CLIB-Graduate Cluster, Herdecke, Germany (2016)
   
• Irene Kaplanow, Gerhard Schembecker, Juliane Merz
  Tunable Aqueous Polymer Phase Impregnated Resins Technology – Investigation of impregnation stability
  Scale-up and scale-down of bioprocesses, Hamburg, Germany (2015)

• I.Kaplanow, G. Schembecker, J. Merz
  Tunable Aqueous Polymer Phase Impregnated Resins Technology – A technology for downstream processing of biological products
  Sixth Annual CLIB-Graduate Retreat, Wermelskirchen, Deutschland (2015)