Dr.-Ing. Pascal Scherpian

Pascal Scherpian graduated from Dortmund University in 2004. He finished his studies in chemical engineering with a thesis on conceptual design of integrated reaction and separation processes.

Employed at the laboratory for plant and process design from January 2005 to September 2008 his research focused on the synthesis of chromatographic separation processes.

As standard unit operation preparative chromatography is a popular technique when it comes to purification of fine chemicals and biotechnological products. Seeking for a fast implementation of chromatographic processes very often classical batch chromatography is applied. With rising production scales and separation cost becoming more important a simulated moving bed (SMB) unit might be considered, instead. However, smaller companies are often reluctant to invest in such complex equipment. In this case advanced batch process concepts like closed-loop (CLRC) and steady-state (SSRC) recycling chromatography are promising alternatives, because they consist of flexible and inexpensive equipment and they can lead to higher yield and productivity. Optimisation and design of recycling chromatography processes form the basis to generate a knowledge base assisting the choice of process concept during process development.

Dissertation

• P. Scherpian
  Zur Auswahl und Auslegung chromatographischer Prozesskonzepte mit Recycling
  TU Dortmund, 2009, Verlag Dr. Hut, München, ISBN 978-3-86853-202-9

Paper

• P. Scherpian, G. Schembecker
  Scaling up Recycling Chromatography
  Chemical Engineering Science, 64 (18), (2009), S. 4068-4080, doi.org/10.1016/j.ces.2009.06.024

Oral presentations

• P. Scherpian, D. Schlinge and G. Schembecker
  Design Method for Closed-Loop and Steady-State Recycling Chromatography
  SPICA - 12th International Symposium on Preparative and Industrial Chromatography and Allied Techniques, Zürich (2008)
   
• P. Scherpian and G. Schembecker
  Design and operation of chromatographic batch processes
  ACHEMA - 28th International Exhibition-Congress on Chemical Engineering, Environmental Protection and Biotechnology, Frankfurt am Main (2006)

Poster presentations

• P. Scherpian, D. Schlinge and G. Schembecker
  Choice of Process Concept in Preparative Chromatography
  SPICA - 12th International Symposium on Preparative and Industrial Chromatography and Allied Techniques, Zürich (2008)
   
• P. Scherpian , S. Felske, G. Schembecker
  Separation of a pharmaceutical intermediate by SMB and batch chromatography
  SPICA - 11th International Symposium on Preparative and Industrial Chromatography and Allied Techniques, Innsbruck (2006)
   
• G. Sand, S. Barkmann, P. Scherpian, M. Tylko, S. Engell and G. Schembecker
  MINLP-Optimization in the Integration of Reaction and Separation Processes
  Sustainable (Bio)Chemical Process Technology, Process Intensification, Delft (2005), 317-324