Telephone
(+49)231 755-2339

Fax
(+49)231 755-2341

Birth name
Jana Bruderreck

Laboratory of Plant and Process Design
Emil-Figge-Str. 70
Geschossbau 2
44227 Dortmund
Deutschland

Room G2-R3.10

Curriculum Vitae

Field of Research

Continuous crystallization is advantageous with regard to batch crystallization because it provides benefits such as consistence of product quality, improved yield and capacity. Before employment in the pharmaceutical industry is possible, a continuous crystallization process needs to meet the requirements for a high crystalline product quality. These requirements include e.g. crystal size and its distribution, yield, and purity. In this context, two apparatus concepts are focused: The Archimedes Tube Crystallizer and the integrated belt filter. 

The Archimedes screw concept promises long residence times and a narrow crystal size distribution for a novel continuous crystallizer implementation. This is advantageous for obtaining consistent in-spec products. Within this thesis, a small scale continuous Archimedes Tube Crystallizer is developed and characterized regarding its operating window to obtain controlled and high crystalline product quality. With the aid of modelling tools, design and operation of the apparatus can be improved further, especially regarding temperature profile and crystal size distribution.

In an integrated belt filter located at KIT University in Karlsruhe, the unit operations crystallization, solid-liquid separation and drying are implemented in one apparatus. This concept eliminates typical transport challenges such as blocking. As the basis for the automation of this apparatus, a modelling approach is developed in this thesis.

Publications

Paper

• Jana Sonnenschein, Mario Hermes, Stefan Höving, Norbert Kockmann, Kerstin Wohlgemuth
  Population balance modeling of unstirred cooling crystallization on an integrated belt filter
  Journal Computers and Chemical Engineering (2022) 10.1016/j.compchemeng.2022.108024 
  
  
• J. Sonnenschein, R. Heming, K. Wohlgemuth
  Archimedes Tube Crystallizer: Design and Operation of Continuous Cooling Crystallization Based on First-Principle Modeling
  Crystal Growth & Design 22, 9 (2022) 5272-5284, doi.org/10.1021/acs.cgd.2c00399
  
  
• J. Sonnenschein, K. Wohlgemuth
  Archimedes tube crystallizer: Design and characterization for small-scale continuous crystallization
  Chemical Engineering Research and Design 178 (2022), 488-501, doi.org/10.1016/j.cherd.2021.12.017
  
  
• J. Sonnenschein, P. Friedrich, M. Aghayarzadeh, O. Mierka, S. Turek, K. Wohlgemuth
  Flow Map for Hydrodynamics and Suspension Behavior in a Continuous Archimedes Tube Crystallizer
  Crystals 11 (2021) 1466

Oral Presentations

• J. Bruderreck, K. Wohlgemuth, G. Schembecker
  Construction and Characterization of a Continuous Archimedes Screw Crystallizer
  Jahrestreffen der ProcessNet-Fachgruppe Kristallisation, Bamberg (2019)

• J. Sonnenschein, M. Hermes, K. Wohlgemuth
  Simulating the influence of material-specific parameters on the operation of a quasi-continuous integrated belt filter
  Jahrestreffen der ProcessNet-Fachgruppe Kristallisation, Virtual Meeting (2021)

• J. Sonnenschein, M. Hermes, K. Wohlgemuth
  Model-based target-size oriented operation of an integrated belt filter
  Jahrestreffen der ProcessNet-Fachgruppe Prozess-, Apparate- und Anlagentechnik, Virtual Meeting (2021)

• J. Sonnenschein, R. Heming, J. Henrichs, K. Wohlgemuth
  How to design and operate an Archimedes Tube Crystallizer for Continuous Cooling Crystallization
  Jahrestreffen der ProcessNet-Fachgruppe Kristallisation, Dortmund (2022)
  
  

Poster Presentations

• J. Sonnenschein, R. Heming, M. Aghayarzadeh, O. Mierka, S. Turek, K. Wohlgemuth
  Using modeling tools to accelerate the design process of the innovative continuous Archimedes Tube Crystallizer
  21st International Symposium on Industrial Crystallization, Virtual Meeting (2021)