Telephone (+49)231 755-2339
Fax (+49)231 755-2341
Laboratory of Plant and Process Design Emil-Figge-Str. 70 Geschossbau 2 44227 Dortmund Germany
Room G2-R3.20
Stefanie Schuldt began studying Biochemical Engineering at the TU Dortmund in 2003 and finished her degree in 2009 with the diploma thesis "Selection of Sorbents using Purification Fingerprints within a Systematic Downstream Process Design". Since May 2009 she works as a PhD student at the laboratory of Plant and Process Design. The focus of her research is "Experimentally based systematic Downstream Process Design".
The performance of a process depends heavily on the decisions made during early stages of downstream process development. Especially for biotechnological products the downstream process often accounts for more than 50% of the total production costs. The aim of this thesis is to develop a method for systematic downstream process design in early stages of process synthesis. Therefore different unit operations, mass separating agents and operating conditions are investigated and compared. This experimental investigation of different process steps is carried out with high-throughput technologies. High-throughput screening (HTS) is a relatively new micro scale technique which allows to quickly prepare and analyze a multiplicity of samples. The application of HTS technologies for downstream process design is a comparatively new field of application. Because of this the development of suitable strategies for the application of this technique is one aspect of this thesis. The experimental approach will be combined with theoretical algorithmic methods. Based on key performance indicators the most promising process alternatives will be used to form an efficient downstream process.
The major objective is to develop a strategy for rapid and comprehensive downstream process development of biotechnological products.
The evaluation of these methods focuses on the isolation of biotechnological products from fermentation broth, for example the purification of secondary metabolites from the supernatant of basidiomycetes.
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